Vioxx (Rofecoxib)
Purpose of Medication and Method of Action
Vioxx is among the first of a new class of antiinflammatory drugs approved for use in both osteo- and rheumatoid arthritis. It acts by inhibiting the enzyme cyclooxygenase-2 (COX-2), a key step in producing prostaglandins. Prostaglandins are one of the mediators of the inflammatory response.
Side Effects
Abdominal pain, dyspepsia, and headache are among the most common. Although this class of drugs may produce less gastrointestinal bleeding than the NSAIDS (ibuprofen and naproxen) it still may occur and if severe gastrointestinal pain should occur or tarry stools, please contact your physician immediately.
Drug Interactions
Vioxx may decrease the effectiveness of ACE inhibitors (Example Accupril) and diuretics such as hydrochlorothiazide (HCTZ)which are antihypertensives. Fluconazole (Diflucan) use will increase blood levels of Vioxx by two-fold and a Vioxx dose reduction may be advisable.
Cautions and Contraindications
A reduction in dose may be necessVioxx should be used with great caution in those with a previous history of gastric bleeding following NSAID ingestion.ary in patients with impaired renal function.
Usual Dose
Osteoarthritis - 12.5mg - 25 mg daily.
Patient Medication Information
These information sheets do not list all known side effects of the medications, only the most common side effects. For a complete list of side effects please contact your local pharmacy or the actual drug manufacturing company.