TEMODAR (Temozolomide)
Purpose of Medication and Method of Action
Temodar is indicated for the treatment of adults with refractory anaplastic astrocytoma. When taken orally, it is converted in the body to its active form MTIC. MTIC is believed to exert its anti-tumor effect by alkylation of DNA thus preventing the growth of the tumor tissue.
Side Effects
Side effects include: nausea (53%), headache (41%), fatigue (tiredness) 34%, convulsions (23%), transient paralysis on one side of body(18%), muscle weakness (13%) and dizziness (12%). Depression of bone marrow elements may occur and careful monitoring of white blood cell count is strongly urged.
Drug Interactions
None reported
Cautions and Contraindications
None
Usual Dose
The usual starting dose is 150 mg/M2 once daily for 5 days per 28 day cycle. If neutrophil and platelet counts are normal, the dose can be increased to 200 mg/M2 5 days per 28 day cycle.
Patient Medication Information
These information sheets do not list all known side effects of the medications, only the most common side effects. For a complete list of side effects please contact your local pharmacy or the actual drug manufacturing company.