Seroquel (Quetiapine)
Purpose of Medication and Method of Action
Seroquel is indicated for the treatment of bipolar mania and schizophrenia. The specific mechanism of action is not known although Seroquel does stimulate a number of brain neuroreceptors with the dopamine receptors potentially involved with its anti-schitzophrenia activity.
Side Effects
Common side effects include: headache (21%), agitation (20%), drowsiness (18%), dizziness (11%), dry mouth (9%) and constipation (8%).
Drug Interactions
Phenytoin and thioridazine can increase the metabolism of Seroquel and require an increase in Seroquel dose to maintain effectiveness. Ketokonazole can reduce the metabolism of Seroquel and require a reduction in dose to avoid side effects.
Cautions and Contraindications
Seroquel may produce a drop in blood pressure upon standing resulting in dizziness. Should this occur getting up slowly is recommended. Use with caution in patients with a history of seizures.
Usual Dose
100-400 mg daily with a maximum of 800 mg daily.
Patient Medication Information
These information sheets do not list all known side effects of the medications, only the most common side effects. For a complete list of side effects please contact your local pharmacy or the actual drug manufacturing company.