Selegiline
Purpose of Medication and Method of Action
Selegiline is used as an adjunct in the treatment of Parkinson¹s disease. It acts by inhibiting the brain enzyme monoamine oxidase Type B. This results in increased levels of dopamine in the brain. A relative deficiency of dopamine is one of the factors believed responsible for Parkinsonism. Selegiline is usually used along with other drugs to treat Parkinson¹s disease such as carbidopa/levodopa.
Side Effects
Nausea, hallucinations, confusion, depression, loss of balance and insomnia are among the most common.
Drug Interactions
Concomitent use of meperidine (Demerol) could result in stupor, rigidity, severe agitation and increased temperature. Use with extreme caution with all antidepressant medication i.e. amitriptyline (Elavil), Paxil and Prozac.
Cautions and Contraindications
None
Usual Dose
Two tablets (5mg) two times a day for a total of 10 mg/day. Do not exceed this dose under any circumstances.
Patient Medication Information
These information sheets do not list all known side effects of the medications, only the most common side effects. For a complete list of side effects please contact your local pharmacy or the actual drug manufacturing company.