Prograf (Tacrolimus)
Purpose of Medication and Method of Action
Prograf is an immuno-supressant which prolongs the survival of the both the host and transplanted organs. It acts by preventing T-lymphocyte activation, an important step in the rejection of transplanted organs.
Side Effects
The most common side effects include: headache (35-65%), tremor (50-60%), diarrhea ((40-70%), tingling of extremities 25-40%), increased blood pressure (50%) and muscle pains (25%).
Drug Interactions
A number of drugs may increase the blood levels and thus the side effects of Prograf and must be used with caution when added to existing Prograf therapy. Among those are the calcium channel blockers (e.g. nifedapine, verapamil), oral antifungal drugs, erythromycin and Biaxin, drugs which increase g.i. motility (metoclopramide and Propulsid), cimetadine, and protease inhibitors. Drugs which may decrease tacrolimus blood levels and decrease effectiveness are: anticonvulsants (Dilantin), phenobarbital, and carbamazepine (Tegretol).
Cautions and Contraindications
Those taking tacrolimus will be more likely to develop infections since their immune system is depressed. Early treatment of infections with the appropriate antibiotic is mandatory.
Usual Dose
0.1-0.2 mg/kg/day every 12 hours. Avoid grapefruit juice. This medication should be taken with cyclosporine.
Patient Medication Information
These information sheets do not list all known side effects of the medications, only the most common side effects. For a complete list of side effects please contact your local pharmacy or the actual drug manufacturing company.