Parnate (Tranylcypromine)
Purpose of Medication and Method of Action
Parnate is an antidepressant which acts by inhibiting monoamine oxidase (MAO). This appears to increase the brain levels of catecholamines. A deficiency of catecholamines may be partly responsible for depression.
Side Effects
The most significant and dangerous side effect is the sudden occurrance of very high blood pressure - this is accompanied by a severe headache unresponsive to mild analgesics. Other common and less serious side effects are: dizziness, sleep disturbances, tiredness, constipation, weight gain, and impotence.
Drug Interactions
There are many drugs which cannot be taken with Parnate. In particular, tricyclic antidepressants such as amitriptyline, cold preparations which contain ephedrine,There are many drugs which cannot be taken with Parnate. In particular, tricyclic antidepressants such as amitriptyline, cold preparations which contain ephedrine.
Cautions and Contraindications
When used with antihypertensives (drugs to lower blood pressure), excessive low blood pressure may occur. Avoid tyramine containing foods and herbs such as liver, cheeses, yeast extract, beer and wine, excessive chocolate and caffeine, and broad bean products. Injestion of these products can produce a sudden and dangerous increase in blood pressure.
Usual Dose
The usual dose is 30 mg a day in divided doses.
Patient Medication Information
These information sheets do not list all known side effects of the medications, only the most common side effects. For a complete list of side effects please contact your local pharmacy or the actual drug manufacturing company.