Meclofenamate
Purpose of Medication and Method of Action
Meclofenamate is a non-steroidal anti-inflammatory drug (NSAID) agent indicated for the treatment of rheumatoid arthritis. It acts by interfering with the synthesis of prostaglandin, a necessary step in the process of inflammation.
Side Effects
The most frequent side effects are gastrointestinal and include diarrhea (20%), nausea (10%), and abdominal pain. The diarrhea may be sever enough to require discontinuation of the drug. Other less common side effects: edema, dizziness and ringing in the ears. Like other NSAIDS, meclofenamate can produce gastrointestinal irritation sever enough to produce bleeding. Should black tarry stools occur while on therapy contact your physician immediately.
Drug Interactions
Meclofenamate will increase the effect of warfarin and the dose of the anticoagulant will need to be reduced at the initiation of meclofenamate therapy.
Cautions and Contraindications
Do not use in individuals with a history of allergy to aspirin or other NSAIDS.
Usual Dose
50-100 mg every four to six hours. The daily should not exceed 400 mg. In the event of gastrointestinal distress it may be taken with milk or meals.
Patient Medication Information
These information sheets do not list all known side effects of the medications, only the most common side effects. For a complete list of side effects please contact your local pharmacy or the actual drug manufacturing company.