Lotrel (Amlodapine and Benazepril)
Purpose of Medication and Method of Action
Lotrel is a combination of two drugs which are used to treat high blood pressure. The drug benazepril acts by inhibiting the action of angiotensin converting enzyme (ACE). This reduces blood pressure by preventing the formation of Angiotensin II, a biochemical produced by the kidney which increases blood sodium (greater water retention). The other drug in this combination product, amlodipine is a calcium channel blocker which produces peripheral dilation thus lowering peripheral resistance and lowering blood pressure.
Side Effects
The most common side effects are: dizziness, a persistent cough, fatigue, and headache. Should the cough become troublesome, contact your physician. Rarely, a condition called angioedema characterized by swelling of the face and hands may occur - if so, call your physician immediately.
Drug Interactions
If used with potassium sparing diuretics such as triamterene, an increase in blood potassium may result with an adverse effect on the heart. Lotrel may reduce the absorption of the antibiotic tetracycline. The blood level of lithium may be increased by Lotrel and extreme caution should be exercised when Lotrel is added to existing lithium therapy.
Cautions and Contraindications
The dose needs to be modified downward if kidney function is impaired.
Usual Dose
Initial - One tablet each day. You should take (or have) your blood pressure taken once weekly and record the value and take with you on next visit to your physician. Most pharmacies have a blood pressure machine available at no charge.
Patient Medication Information
These information sheets do not list all known side effects of the medications, only the most common side effects. For a complete list of side effects please contact your local pharmacy or the actual drug manufacturing company.