Imipramine
Purpose of Medication and Method of Action
Imipramine belongs to a class of drugs called the tricyclic antidepressants. They may act by preventing the uptake of norepinephrine by nerves in the central nervous system. This allows for increased amounts of norepinephrine to be available outside the nerve with the resultant improvement in depression. It is also indicated in the treatment of childhood enuresis (bedwetting).
Side Effects
None
Drug Interactions
Quinidine (for heart) and cimetadine (for stomach acid) may increase blood levels and side effects when added to existing imipramine therapy. Use with caution with antidepressants which work via a SRRS (serotonin reuptake) mechanism such as Prozac and Paxil). Use with caution with other drugs with anticholinergic properties such as antihistamines and anti-parkinson drugs.
Cautions and Contraindications
The class of antidepressants, MAO inhibitors such as Nardil must not be used with imipramine! Use with caution in those who have had a recent myocardial infarction (heart attack).
Patient Medication Information
These information sheets do not list all known side effects of the medications, only the most common side effects. For a complete list of side effects please contact your local pharmacy or the actual drug manufacturing company.