Diflucan (Fluconazole)
Purpose of Medication and Method of Action
Diflucan is an antifungal drug used to both prevent and treat oral and vaginal infections due to Canadida albicans. It is also used intravenously to treat cryptococcal menginitis. It acts by inhibiting the ability of the fungus to produce sterols which are necessary for survival of the microorganism.
Side Effects
The most common side effects are: headache (13%),nausea (7%), vomiting (5%) and abdominal pain (6%). There have been rare reports of severe liver damage thus patients on long-term therapy should have liver function tests done by their physician at regular intervals.
Drug Interactions
Diflucan slows the metabolism of a number of drugs including Coumarin (warfarin)-like anticoagulants, phenytoin (Dilantin), theophylline, and Propulsid. In each case, the blood level of the affected drug will increase thus increasing the liklihood of dose-related adverse effects.
Cautions and Contraindications
None
Usual Dose
For vaginal candidiasis: 150 mg once only. For other fungal infections 200 mg for first dose and 100-400mg/day thereafter. For prophylaxis in patients with bone marrow transplants 400 mg once daily.
Patient Medication Information
These information sheets do not list all known side effects of the medications, only the most common side effects. For a complete list of side effects please contact your local pharmacy or the actual drug manufacturing company.