Colchicine
Purpose of Medication and Method of Action
Colchicine is used for the treatment of the pain associated with acute attacks of gout. It may act by decreasing uric acid production by leukocytes (white blood cells) and by reducing components of the inflammatory process.
Side Effects
The most common side effects are: vomiting, nausea, and diarrhea at higher doses. Should this occur colchicine must be stopped. The most dangerous side effects are: bone marrow depression, loss of feeling in extremities, and muscle pain. Hair loss has been reported occasionally.
Drug Interactions
Urinary acidifiers and alkalinizing agents will affect colchicine blood levels and thus reduce effectiveness or increase toxicity.
Cautions and Contraindications
None
Usual Dose
To abort an attack - 1-2 mg (2-4 tablets) followed every hour by one tablet until pain relief occurs or until diarrhea ensues. To reduce the occurrence of attacks, one tablet each day for 3-4 days each week.
Patient Medication Information
These information sheets do not list all known side effects of the medications, only the most common side effects. For a complete list of side effects please contact your local pharmacy or the actual drug manufacturing company.