Citalopram (Celexa)
Purpose of Medication and Method of Action
Citalopram is indicated for the treatment of major depression. It is an SSRI (Selective Serotonin Reuptake Inhibitor). The similar medications in this class act by increasing the amount of serotonin available extracellularly in the central nervous system. This increase in serotonin is believed to improve mood and reduce the symptoms of depression.
Side Effects
Side effects resulting in discontinuation of therapy occur in 16% of patients taking citalopram. The most common are: agitation (3%), anxiety (4%), insomnia (15%), drowsiness (18%), sweating (11%), tremor (8%), dry mouth (20%), nausea (21%), and abnormal ejaculation (6%).
Drug Interactions
Drugs taken with citalopram which decrease its effectiveness are: cyproheptadine, barbiturates, and phenytoin. Cigarette smoking will also decrease the effectiveness of citalopram. Drugs which increase citalopram blood levels and dose-related side effects are: cimetadine, linezolid, MAOI inhibitors, St. Johns Wort, and lithium carbonate. Note: This list is not complete.
Cautions and Contraindications
Patients taking Citalopram and other SSRI’s may experince a worsening of their depression and become more prone to suicide. Citalopram should be used with caution in patients with impaired liver function.
Usual Dose
initially 20 mg daily increasing to 40 mg maintenance dose.
Patient Medication Information
These information sheets do not list all known side effects of the medications, only the most common side effects. For a complete list of side effects please contact your local pharmacy or the actual drug manufacturing company.