Avandia (Rosiglitazone)
Purpose of Medication and Method of Action
Avandia is indicated as monotherapy for the treatment of maturity onset (Type 2) diabetes. Avandia acts by improving the sensitivity of cells to the effect of circulating insulin on liver, muscle and fat cells. It is of particular value in overcoming the insulin resistance characteristic of Type 2 diabetes. Avandia is the second drug in this class of agents. The first, Rezulin, has been associated with the occurance of severe liver damage.
Side Effects
Among the more common side effects are: headache, edema (swelling of ankles) due to increased volume of blood, and anemia (decreased red blood cells). Although significant liver damage has not been reported with Avandia, liver function studies should be performed every 2 months for the first year of therapy.
Drug Interactions
None reported.
Cautions and Contraindications
Avandia should be used with caution in presence of edema. Blood volume expansion due to Avandia may worsen existing heart failure.
Usual Dose
The usual starting dose is 4 mg once daily or in divided doses. For maximum response the dose may be increased to 8 mg daily.
Patient Medication Information
These information sheets do not list all known side effects of the medications, only the most common side effects. For a complete list of side effects please contact your local pharmacy or the actual drug manufacturing company.