Arthrotec (Diclofenac plus Misoprostol)
Purpose of Medication and Method of Action
Arthrotec contains a combination of two drugs and is indicated for the treatment of arthritis. Diclofenac is a nonsteroidal antiinflammatory drug (NSAID) which interferes with the inflammatory process by blocking the production of prostaglandins. Misoprostol is a synthetic analogue of prostaglandin. A depletion of prostaglandin in the stomach is believed to be responsible for the development of stomach irritation and bleeding observed with many NSAIDS. Thus this combination provides antiinflammatory activity of a NSAID with a lower incidence of gastrointestinal irritation and bleeding.
Side Effects
The most common is abdominal pain (15%), diarrhea (11%), heartburn (11%), nausea (6%) and flatulence (4%). Occasionally fluid retention with peripheral edema may occur.
Drug Interactions
Do not use this combination with aspirin which will decrease the activity of diclofenac. The combination may also increase blood levels and side effects of digoxin, methotrexate, cyclosporin, and lithium.
Cautions and Contraindications
Use with caution in aspirin-sensitive asthma, the combination is contraindicated in pregnancy.
Usual Dose
Either Arthrotec 50, 2-3 times a day or Arthrotec 75, two times a day. Arthrotec 50 50 mg diclofenac with 200 mcg misoprostol, Arthrotec 75 75 mg diclofenac with 200 mcg misoprostol.
Patient Medication Information
These information sheets do not list all known side effects of the medications, only the most common side effects. For a complete list of side effects please contact your local pharmacy or the actual drug manufacturing company.